NRF and Frip sample NRF Frip ESCH3K27acX1 0.9969 0.1038 ESCH3K27acX2 0.9989 0.0848 ESCH3K4me3X1 0.9631 0.6642 ESCH3K4me3X2 0.9797 0.5582 NPCH3K27acX1 0.9978 0.0586 NPCH3K27acX2 0.9989 0.0287 NPCH3K4me3X1 0.9960 0.2594 NPCH3K4me3X2 0.9988 0.0979 NeuronH3K27acX1 0.9987 0.0935 NeuronH3K27acX2 0.9991 0.0805 NeuronH3K4me3X1 0.9983 0.1584 NeuronH3K4me3X2 0.9988 0.0930 Jaccard index between replicates ESC 23176 35971 23247 0.647549 H3K4me3 NPC 61305 100333 10805 0.0716355 H3K4me3 Neuron 59541 49976 15634 0.166526 H3K4me3 ESC 82051 159525 16838 0.0749228 H3K27ac NPC 55196 36825 3488 0.0393977 H3K27ac Neuron 103204 90758 6949 0.0371578 H3K27ac # of candidate ELSs stage all distal ESC 8868 6998 NPC 2318 1021 Neuron 4718 3050 # of intronic/intergenic distal ELSs stage distal distal_intronic distal_intergenic ESC 6998 3736 3178 0.533867 0.45413 NPC 1021 499 508 0.488737 0.497551 Neuron 3050 1620 1392 0.531148 0.456393 # of candidate ELSs intersecting with adult tissue-specific ELSs tissue ESC NPC Neuron blood 2 1 1 muscle_smooth 7 3 6 muscle_skeletal_cardiac 19 3 3 brain 43 6 34 fibro_myoblasts 9 2 17 iPS 538 35 36 digestive 2 0 2 mucosa 14 2 4 aorta 18 2 4 common 36 28 37 # of candidate ELSs intersecting with embryo tissue-specific ELSs tissue ESC NPC Neuron differentiated_tissues 16 8 13 neural_progenitors 19 1 10 stem_cells 273 4 9 common 14 5 19 # of adult tissue-specific ELSs intersecting with candidate ELSs tissue ESC NPC Neuron blood 2 1 1 muscle_smooth 7 4 6 muscle_skeletal_cardiac 22 3 3 brain 44 5 34 fibro_myoblasts 11 2 18 iPS 616 45 38 digestive 2 0 2 mucosa 20 2 4 aorta 20 2 4 common 37 29 39 # of embryo tissue-specific ELSs intersecting with candidate ELSs tissue ESC NPC Neuron differentiated_tissues 15 8 12 neural_progenitors 18 1 9 stem_cells 299 4 10 common 13 5 19