NRF and Frip sample NRF Frip ESCH3K27acX1 0.9969 0.1833 ESCH3K27acX2 0.9989 0.0808 ESCH3K4me3X1 0.9631 0.7459 ESCH3K4me3X2 0.9797 0.6549 NPCH3K27acX1 0.9978 0.0692 NPCH3K27acX2 0.9989 0.0255 NPCH3K4me3X1 0.9960 0.2944 NPCH3K4me3X2 0.9988 0.0770 NeuronH3K27acX1 0.9987 0.1104 NeuronH3K27acX2 0.9991 0.0715 NeuronH3K4me3X1 0.9983 0.1928 NeuronH3K4me3X2 0.9988 0.1013 Jaccard index between replicates ESC 23436 32432 22897 0.694459 H3K4me3 NPC 46290 69390 12670 0.122998 H3K4me3 Neuron 57883 45128 19411 0.232189 H3K4me3 ESC 133144 126932 20555 0.0858171 H3K27ac NPC 48413 33259 3369 0.0430252 H3K27ac Neuron 89280 76124 10793 0.0698075 H3K27ac # of candidate ELSs stage all distal ESC 12093 9546 NPC 2067 1073 Neuron 7119 4836 # of intronic/intergenic distal ELSs stage distal distal_intronic distal_intergenic ESC 9546 5753 3666 0.602661 0.384035 NPC 1073 642 412 0.598322 0.38397 Neuron 4836 2977 1782 0.615591 0.368486 # of candidate ELSs intersecting with adult tissue-specific ELSs tissue ESC NPC Neuron blood 3 0 1 muscle_smooth 8 4 14 muscle_skeletal_cardiac 17 6 7 brain 62 7 119 fibro_myoblasts 6 1 24 iPS 1277 69 71 digestive 1 0 1 mucosa 16 1 3 aorta 7 2 11 common 66 42 90 # of candidate ELSs intersecting with embryo tissue-specific ELSs tissue ESC NPC Neuron differentiated_tissues 21 6 38 neural_progenitors 17 7 33 stem_cells 685 12 11 common 23 15 34 # of adult tissue-specific ELSs intersecting with candidate ELSs tissue ESC NPC Neuron blood 3 0 1 muscle_smooth 7 5 14 muscle_skeletal_cardiac 19 5 7 brain 65 6 117 fibro_myoblasts 7 1 22 iPS 1458 76 71 digestive 1 0 1 mucosa 17 1 3 aorta 8 2 11 common 62 44 95 # of embryo tissue-specific ELSs intersecting with candidate ELSs tissue ESC NPC Neuron differentiated_tissues 20 6 36 neural_progenitors 15 6 28 stem_cells 718 12 11 common 19 14 32